Spermatozoa DNA damage measured by sperm chromatin structure assay (SCSA) and birth characteristics in children conceived by IVF and ICSI
نویسندگان
چکیده
منابع مشابه
The sperm chromatin structure assay (SCSA) as prognostic factor in IVF/ICSI program.
In this study 60 couples undergoing intracytoplasmic sperm injection (ICSI) procedures were enrolled. All men were classified into two groups regarding to the DNA fractionation index (DFI) threshold value: group I < 15% and group II =or> 15%. In group I, median DFI was 4%, normal pre-implantation embryo development was observed and eleven pregnancies were achieved. In group II, median DFI was 2...
متن کاملEnvironmental toxicants cause sperm DNA fragmentation as detected by the Sperm Chromatin Structure Assay (SCSA).
Studies over the past two decades have clearly shown that reproductive toxicants cause sperm DNA fragmentation. This DNA fragmentation can usually be detected prior to observing alterations of metaphase chromosomes in embryos. Thus, Sperm Chromatin Structure Assay (SCSA)-detected DNA damage is viewed as the molecular precursor to later gross chromosome damage observed under the light microscope...
متن کاملDNA damage in patients with untreated cancer as measured by the sperm chromatin structure assay.
OBJECTIVE To examine the relationship between sperm chromatin defects, evaluated by sperm chromatin structure assay (SCSA) and semen characteristics in cryopreserved semen specimens from patients diagnosed with various types of cancer. DESIGN Prospective study. SETTING Andrology laboratory at a tertiary care hospital. PATIENT(S) Cryopreserved semen samples from 12 healthy fertile men and ...
متن کاملPERINATAL EPIDEMIOLOGY Birth defects in children conceived by ICSI compared with children conceived by other IVF-methods; a meta-analysis
have become available for most categories of infertile couples. In 1988, Lanzendorf et al. reported an experiment with intracytoplasmic sperm injection (ICSI) on human oocytes,1 and in 1992, ICSI was presented as a successful method of treatment for certain types of male infertility.2 The ICSI procedure involves the isolation of one particular spermatozoon that is subsequently injected directly...
متن کاملSperm DNA damage and its role in IVF and ICSI
While the semen analysis has traditionally been relied upon to differentiate fertile and infertile men, its utility has been questioned in the current era of assisted reproductive technologies. The desire for more sophisticated diagnostic and predictive tools has led to increased use of sperm DNA damage in the management of male infertility. Despite the availability of numerous assays to measur...
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ژورنال
عنوان ژورنال: International Journal of Andrology
سال: 2011
ISSN: 0105-6263
DOI: 10.1111/j.1365-2605.2011.01222.x